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 Post subject: Alcohol
PostPosted: Wed Apr 05, 2006 10:32 am 
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so just gonna go on a lil rant here, just cause i want to start a thread.

so, in october i got fucked by having 3 kegs and way too many people at our house (im in college). mix in some asshole cops and you get some pretty heavy fines (furnishing to minors, hosting a party...). so i cut a deal with the city attorney to do diversion, admit guilt, pay less, take some gay ass classes at my university, etc. sooooo, months later i finally get around to taking the gay ass class. today i had a meeting with a grad student in the health building who asked me all about my drinking habbits.

first off i got very drunk the night before and only by miracle did i wake up in time for this 10am meeting. i am hung over and stink of booze. she asks me if i do things i dont remember when i drink and if i do things i regred or that are dangerous. at that instand i remeberd skateboarding home drunk as a skunk the night before down a giant hill with a blind turn at the bottom, at night, with a backpack on. its crazy because i have never had the balls to do it sober. so i just busted out laughing, and told her "no i never put myself in danger when i drink..."

so thats my story

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PostPosted: Wed Apr 05, 2006 12:49 pm 
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Complaining or boasting?


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PostPosted: Wed Apr 05, 2006 1:44 pm 
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That party was EPIC!
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PostPosted: Thu Apr 06, 2006 3:38 pm 
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Location: santa rosa,CA
completely blasted now.guess will have to do TIME in purgatory-I mean,Northern California.

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Last edited by zzyrch on Sat Jun 10, 2006 8:44 pm, edited 2 times in total.

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PostPosted: Thu Apr 06, 2006 9:25 pm 
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Location: the other twilight zone
alcohol is good for desinfecting...

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PostPosted: Sat Jun 10, 2006 8:46 pm 
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----GO TO A CHURCH OF YOUR CHOICE TO GET LAID---GO TO A PUB OF YOUR CHOICE TO FIND FIND god.......

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 Post subject: Re: Alcohol
PostPosted: Sun Jun 11, 2006 1:28 am 
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Posts: 817
Location: Boston, mASSHOLEchusetts, USA
bunsup wrote:
so just gonna go on a lil rant here, just cause i want to start a thread.

so, in october i got fucked by having 3 kegs and way too many people at our house (im in college). mix in some asshole cops and you get some pretty heavy fines (furnishing to minors, hosting a party...). so i cut a deal with the city attorney to do diversion, admit guilt, pay less, take some gay ass classes at my university, etc. sooooo, months later i finally get around to taking the gay ass class. today i had a meeting with a grad student in the health building who asked me all about my drinking habbits.

first off i got very drunk the night before and only by miracle did i wake up in time for this 10am meeting. i am hung over and stink of booze. she asks me if i do things i dont remember when i drink and if i do things i regred or that are dangerous. at that instand i remeberd skateboarding home drunk as a skunk the night before down a giant hill with a blind turn at the bottom, at night, with a backpack on. its crazy because i have never had the balls to do it sober. so i just busted out laughing, and told her "no i never put myself in danger when i drink..."

so thats my story
Well, how often do you get blasted, bunsup? Do you wear very baggy pants with lots of pockets to stuff with nips so you can first be heard approaching by that "clinking" sound of all those little nips before you can be seen? Or am I drawing a really too radical picture here? :mrgreen:

--Batchain :wink:

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PostPosted: Sun Jun 11, 2006 4:23 am 
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zzyrch wrote:
----GO TO A CHURCH OF YOUR CHOICE TO GET LAID---GO TO A PUB OF YOUR CHOICE TO FIND FIND god.......


LMAO :mrgreen: :mrgreen: :mrgreen: :mrgreen: :mrgreen: :mrgreen: :mrgreen: :mrgreen: :mrgreen: :mrgreen: :mrgreen: :mrgreen:

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 Post subject: Re: Alcohol
PostPosted: Sun Jun 11, 2006 5:12 am 
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Posts: 826
Location: Virginia
bunsup wrote:
so just gonna go on a lil rant here, just cause i want to start a thread.

s
first off i got very drunk the night before and only by miracle did i wake up in time for this 10am meeting. i am hung over and stink of booze. she asks me if i do things i dont remember when i drink and if i do things i regred or that are dangerous. at that instand i remeberd skateboarding home drunk as a skunk the night before down a giant hill with a blind turn at the bottom, at night, with a backpack on. its crazy because i have never had the balls to do it sober. so i just busted out laughing, and told her "no i never put myself in danger when i drink..."

so thats my story


So, which detox clinic did they send you? 8)


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PostPosted: Sun Jun 11, 2006 10:33 am 
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Location: Chicago, sort of.
I think you have us confused with AA.

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Everytime we picked a booger we'd flip it on this one winduh. Every night we'd contribute, 2, 3, 4 boogers. We had to use a putty knife, man, to get them damn things off the winduh. There was some goober ones that weren't even hard...


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 Post subject: Re: Alcohol
PostPosted: Wed Jul 03, 2019 9:44 am 
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Location: Over there! (last)
A Jim Beam warehouse filled with 40,000 barrels of bourbon caught fire

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Flames rise from the site of the Kentucky bourbon warehouse Wednesday.

(CNN) A Jim Beam warehouse caught fire late Tuesday and firefighters struggled to contain the massive blaze, partly because of alcohol in the debris.

The warehouse, in Versailles, Kentucky, caught fire around 11:30 p.m. Police Lt. Michael Fortney said a security guard called to report the fire.

Forty firefighters from five counties helped battle the blaze. A second warehouse also caught fire, but that blaze was controlled.

The warehouse where the fire started has collapsed. It held approximately 40,000 barrels of spirits. CNN reached out to Beam Suntory, the parent company of Jim Beam, for comment but has not received a response.

Woodford County Emergency Management chief Drew Chandler said the warehouses are massive -- about the same area as a football field and six or seven stories high.

Fortney said there was lightning in the area Tuesday night and it's possible that it could have sparked the flames. Chandler said the fire had been way too big and hot to get a fire investigator near it. Even as the sun rose Wednesday, the blaze was still roaring.

"It's purposefully being allowed to burn for several more hours," Chandler said. "The more it burns, the less distilled spirits are in the debris."

That will also help ensure any runoff from the firefighting efforts don't pollute nearby sources of drinking water.

In 2018, about 18,000 barrels of bourbon were lost when a warehouse in Bardstown, Kentucky, collapsed during building work. The bourbon run off killed about 1,000 fish in nearby waterways.


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 Post subject: Re: Alcohol
PostPosted: Wed Jul 03, 2019 11:36 am 
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Location: Somewhere in time
The price of this liquor should go up... :idea:


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 Post subject: Re: Alcohol
PostPosted: Wed Jul 03, 2019 11:46 am 
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Posts: 8772
Location: The Thumb
Now listening to a live version of "Alcohol" by the Kinks 8)
https://www.youtube.com/watch?v=YuLzmupBTMs

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 Post subject: Re: Alcohol
PostPosted: Wed Jul 03, 2019 1:09 pm 
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Location: misanthropia
Plook wrote:
This liquor should be free

repaired it.

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 Post subject: Re: Alcohol
PostPosted: Sat Jul 06, 2019 5:29 pm 
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Location: Over there! (last)
Dave Granlund
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 Post subject: Re: Alcohol
PostPosted: Sun Jul 07, 2019 1:01 am 
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Joined: Mon Jan 03, 2005 7:51 pm
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Location: >>==> Wellington New Zealand
Jim Beam had been my spirit of choice since my late teens and being a creature of habit it wasn't until around mid 1995, at a noisy gang pad party someone handed me the first of many very large glasses of Jack Daniels.....I never went back to Jim.....

I'm sad in a nostalgic way about the Jim Beam factory fire, rather than the utter desolation I'd be feeling if it had been gallons of aged Jack Daniels up in smoke or flowing down the river gone forever.....


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 Post subject: Re: Alcohol
PostPosted: Thu Jul 18, 2019 9:26 am 
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Location: Oregon
A Landmark Study on the Origins of Alcoholism

https://getpocket.com/explore/item/a-landmark-study-on-the-origins-of-alcoholism?utm_source=pocket-newtab

By studying rats in a smarter way, scientists are finally learning something useful about why some drinkers become addicted and others don’t.

Only 15% of regular drinkers become dependent on alcohol.

For Markus Heilig, the years of dead ends were starting to grate.

A seasoned psychiatrist, Heilig joined the National Institutes of Health in 2004 with grand ambitions of finding new ways to treat addiction and alcoholism. “It was the age of the neuroscience revolution, and all this new tech gave us many ways of manipulating animal brains,” he recalls. By studying addictive behavior in laboratory rats and mice, he would pinpoint crucial genes, molecules, and brain regions that could be targeted to curtail the equivalent behaviors in people.

It wasn’t to be. The insights from rodent studies repeatedly proved to be irrelevant. Many researchers and *SPAM* companies became disillusioned. “We cured alcoholism in every rat we ever tried,” says Heilig, who is now at Linköping University in Sweden. “And at the end of every paper, we wrote: This will lead to an exciting treatment. But everything we took from these animal models to the clinic failed. We needed to go back to the drawing board.”

Heilig doesn’t buy that mice and rats have nothing to teach us about addiction. It’s more that researchers have been studying them in the wrong way. Typically, they’ll let the animals self-administer drugs by pressing a lever, which they almost always learn to do. That should have been a red flag. When humans regularly drink alcohol, only 15 percent or so become dependent on the stuff. Why them and not the other 85 percent? That’s the crucial question, and you won’t answer it with an experiment in which every rodent becomes addicted.

Eric Augier, who recently joined Heilig’s team, tried a different approach—one pioneered in his former laboratory to study cocaine addiction. After training rats to self-administer alcohol, he offered them some sugary water, too. This better mimics real life, in which drugs exist simultaneously with other pleasurable substances. Given a choice between booze and nectar, most rats chose the latter. But not all of them: Of the 32 rats that Augier first tested, four ignored the sugar and kept on shooting themselves up with alcohol.

“Four rats is laughable,” says Heilig, referring to the study’s small size, “but 620 rats later, no one’s laughing.” Augier repeated the experiment with more rats of various breeds, and always got the same results. Consistently, 15 percent of them choose alcohol over sugar—the same number as the proportion of human drinkers who progress to alcoholism.

Those alcohol-preferring rats showed other hallmarks of human addiction, too. They spend more effort to get a sip of alcohol than their sugar-preferring peers, and they kept on drinking even when their booze supply was spiked with an intensely bitter chemical or paired with an electric shock. “That was striking to me, as a clinician,” says Heilig. “Embedded in the criteria for diagnosing alcoholism is that people continue to take drugs despite good knowledge of the fact that it will harm or kill them.”

Many lab studies treat animals as if they were identical, and any variation in their behavior is just unhelpful noise. But in Augier’s work, the variation is the important bit. It’s what points to the interesting underlying biology. “This is a really good study,” says Michael Taffe, a neuroscientist at the Scripps Research Institute who studies drug addiction. “Since only a minority of humans experience a transition to addiction, [an approach] such as this is most likely to identify the specific genetic variants that convey risk.”

That is exactly what the team did next. They compared the alcohol-preferring and sugar-preferring rats and looked for differences in the genes that were active in their brains. They focused on six regions that are thought to be involved in addiction, and found no differences in five. “But in the sixth, we did,” says Heilig. “And it made me smile because I started out doing my Ph.D. on the amygdala.”

The amygdala is an almond-shaped region that sits deep within the brain, and is heavily involved in processing emotions. When Augier looked at the amygdala of alcoholic rats, he found signs of unusually low activity in several genes, all of which are linked to a chemical called GABA.

GABA is a molecular red light: Certain neurons make and release it to stop their neighbors from firing. Once that’s done, the GABA-making neurons use an enzyme called GAT3 to pump the molecule back into themselves, so they can reuse it. But in the amygdala of alcohol-preferring rats, the gene that makes GAT3 is much less active, and makes just half the usual levels of the pump. GABA accumulates around the neighboring neurons, making them abnormally inactive.

The consequences of this are unclear, but Heilig thinks that all this extra GABA hampers the rats’ ability to deal with fear and stress. They are naturally more anxious, which might explain their vulnerability to alcohol. He predicts it will take another five years of work to fully close this loop. But for now, his team have definitely shown that GAT3—the GABA-recycling pump—is important. They took rats that prefer sugar and deliberately reduced the levels of GAT3 in their amygdala. This simple procedure was enough to convert those resilient rodents into addiction-prone, alcohol-preferring 15-percenters.

At this point, the team submitted their result to a journal, which agreed to publish them. Good news—but after Heilig’s long history with rat-shaped dead-ends, he wanted to do one more experiment. “Curing alcoholism in rats is not important,” he says. “What’s important is what this looks like in humans with alcohol addiction.”

As it happens, it looks much the same. Heilig’s colleagues examined postmortem tissue samples from people who had donated their brains to research, some of whom had alcohol addiction. As in the rats, they found nothing unusual in five of six brain regions. But in the amygdala, they found low levels of GAT3.

Others scientists have found connections between alcoholism, the amygdala, and GABA-related genes. But by identifying rats that are particularly vulnerable to alcoholism, Heilig’s team has begun fleshing out the details behind these somewhat hazy links. “It is a very significant study that will impact the alcohol research field deeply,” says Jun Wang from Texas A&M University. “Identifying GAT3 is not that important because alcoholism is controlled by multiple genes, but [the team’s new approach] will help to find those genes. It’s a wonderful method for modeling human alcoholism.”

There are other signs that what Heilig found is relevant to humans as well as rats. A decade ago, a French cardiologist named Olivier Ameisen claimed to have cured his own alcoholism by taking a drug called baclofen. “That was met with skepticism, and there was no basic science to support his claims,” says Heilig. But there is now: Baclofen stops neurons from releasing GABA. If individuals with alcoholism aren’t good at recycling this chemical, it might be possible to compensate by producing less of it in the first place.

But baclofen is controversial. It has been tested in several clinical trials, to mixed results. Two studies, which analyzed the results from these trials, concluded that the drug’s ability to treat alcoholism is only “slightly above placebo effects” and its growing use is “premature.” It can be harmful, too. People quickly build up a tolerance to it, which prompts them to seek higher doses. They can experience severe side effects, and France has seen more than 100 cases of people inadvertently poisoning themselves with baclofen. “It’s a terrible drug,” Heilig says.

Other drugs like benzodiazepines also exert their effects through GABA, but like baclofen, they’re easily abused themselves. “They’re a good alternative for alcoholism in the short term but they’re not safe in the long term,” says Lara Ray from UCLA.

But Heilig’s study suggests that other chemicals, which could influence GABA levels in more subtle ways, might help people to control their addictions. Several such substances are in development, and Heilig’s team can see if they change the choices of their alcohol-preferring rats.

“It’s just such an impressive breakthrough for the field of alcoholism, with real potential for therapies,” Ray adds.


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 Post subject: Re: Alcohol
PostPosted: Tue Sep 10, 2019 2:15 am 
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my last ocean of alcohol intake occurred on 6/10/17.

so far = so good
#ondryland

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 Post subject: Re: Alcohol
PostPosted: Tue Sep 10, 2019 5:33 am 
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lapsed maps wrote:
my last ocean of alcohol intake occurred on 6/10/17.

so far = so good
#ondryland

Congrats!
Ironically enough your last bender took place on my birthday!
I'm currently staring down the barrel of 5 years without alcohol and don't regret it one bit.
It gets easier with time. Hang in there.


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