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PostPosted: Sat Sep 09, 2017 1:37 pm 
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Mr_Green_Genes wrote:
If you are using it to substitute raw smoke, your good health is worth it. It is priceless, you know... Although I was kind of surprised to learn that tobacco or even nicotine itself is carcinogen. I used to think only the byproducts of combustion alone were the carcinogen part of the smoke.


That's true, but I've never seen the logic of still spending a lot of money after you've kicked the cigarette habit. I'm not saying they shouldn't though, people should be free to do what they want. And slime may be independently wealthy, as much as I know about him. :)


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PostPosted: Fri Nov 03, 2017 3:25 am 
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Brazilian PhD candidate wins Science journal contest to dance-explain your research:

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PostPosted: Fri Nov 03, 2017 7:33 am 
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Just some passing thoughts...

I was a cigarette smoker for ~25 years and struggled badly when trying to quit, failing and going back at least three times...both the physical nicotine and habitual addictions were overwhelming, (but yes, it's way worth it to quit)... So to me is seems, why hang on to the nicotine addiction when it doesn't do anything for you...there are other things one can smoke which DO do things for you...and these can be better vaporized to eliminate exposures to the myriad of combustion by-products...even better to use quality vaporizers that use ceramics to eliminate the vaporizer itself from inserting damaging chemicals.

It might be helpful too to not limit oneself to only considering the dangers of cancers. In general, if something is shortening your telomeres and weakening dna to cause senescence and/or replicating dna mutations (cancer), it might be helpful to recognize if something is shortening telomers to cause cancer, they are also short enough to cause diabetes (shortened telomeres in pancreas), atherosclerosis (shortened telomeres in endothelial cells causing cholesterol to stick building up plaques), dementia, copd, stroke, immune weakening and elevated WBC damaging everything everywhere at once, shortened health span with lengthened disease span, and so on.

If something is damaging telomeres to cause cancer, it is causing everything else at the same time and it's just a matter of which symptoms appear first.

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PostPosted: Mon Nov 20, 2017 2:09 am 
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PostPosted: Sat May 12, 2018 10:37 am 
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One for Mr. G G

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hey punk where you going with that golf club in your hand, again.....


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PostPosted: Tue May 15, 2018 2:57 pm 
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Cool!

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PostPosted: Fri Apr 03, 2020 2:30 am 
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The central scrutinizer, I mean, dogma of molecular biology:

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All the modern wonders of genetics are based on this simple conceptual model called the Central "Dogma".

DNA is needed to create more DNA (Replication)

DNA is needed to create RNA (Transcription)

RNA is needed to create Proteins (Translation)

RNA can be used as a starting point to create DNA (retrotranscription, used in trendy retroviruses)

Gray_Ghost wrote:
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PostPosted: Fri Apr 03, 2020 4:11 am 
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This is so cool!
Thank You GG!
:mrgreen: :mrgreen: :mrgreen:

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PostPosted: Sat Apr 04, 2020 4:54 am 
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Mr_Green_Genes wrote:
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This picture also proves you have green ladybugs living inside your cells. They are called midichlorians... :roll:

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 Post subject: What's new in Baltimore
PostPosted: Thu Apr 09, 2020 1:18 pm 
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Baltimore classification

The Baltimore classification, developed by David Baltimore, is a virus classification system that groups viruses into families, depending on their type of genome (DNA, RNA, single-stranded (ss), double-stranded (ds), etc..) and their method of replication.

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Classifying viruses according to their genome means that those in a given category will all behave in much the same way, which offers some indication of how to proceed with further research. Seven Baltimore classes:

I: dsDNA viruses (e.g. Adenoviruses, Herpesviruses, Poxviruses)
II: ssDNA viruses (+ strand or "sense") DNA (e.g. Parvoviruses)
III: dsRNA viruses (e.g. Reoviruses)
IV: (+)ssRNA viruses (+ strand or sense) RNA (e.g. Coronaviruses, Picornaviruses, Togaviruses)
V: (−)ssRNA viruses (− strand or antisense) RNA (e.g. Orthomyxoviruses, Rhabdoviruses)
VI: ssRNA-RT viruses (+ strand or sense) RNA with DNA intermediate in life-cycle (e.g. Retroviruses)
VII: dsDNA-RT viruses DNA with RNA intermediate in life-cycle (e.g. Hepadnaviruses)

[key: ds=double stranded nucleic acid; ss=single stranded]


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 Post subject: What PCR is!
PostPosted: Thu Apr 16, 2020 9:28 am 
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PCR

PCR, is short for the Polymerase Chain Reaction, is a cornerstone invention in the human history and a true revolution for Molecular Biology studies. Its impact were not only to democratize the genetic research outside model organisms (rat, fruit-fly, yeast and a handful of other organisms and crops) and to leverage the exponential development of molecular genetics within the lasts decades, but to effectively deliver genetic science to Law Courts, criminal investigation and society at large.

PCR was invented in the middle of the 80s by Kerry Mullis, for which he was awarded a Nobel in 1992. He is a odd scientist who is a surfer, defends the use of kool-aid to mind expanding and who allegedly was abducted by a fluorescent racoon...

The power of PCR is that it allows for very scarce, or old or residual DNA to be recovered from samples, crime sites, the environment, etc. It rely on partially/fully knowing characteristics of the target sequence and allows for the exponential replication of a delimited segment of a double-helix DNA molecule, generating literally billions of copy of that particular fragment, in over 2 hours. This is achieved through the use of a pair of DNA primers (short 20-ish bases single-stranded DNA piece, that fits specifically into a region of the target are. With one primer to each DNA strand, the Polymerase enzyme, responsible for synthesizing new complimentary DNA to the template strands, generating new strands to be primed. Repeating cycles of DNA denaturing (separating the double helix into single strands using heat):

https://www.youtube.com/watch?v=2KoLnIwoZKU

In the context of COVID-19, since its cause, the SARS-CoV-2 virus is a RNA virus, first one has to convert the RNA into DNA through means of an enzyme called Reverse Transcriptase. Also, the golden pattern is through the use of a variant technique called quantitative PCR (qPCR), which is also called Real Time - PCR, sometimes also called RT-PCR which can cause confusion to if one is referring to Real-Time (i.e. quantitative PCR) or to Reverse Transcriptase PCR (RT-PCR de facto).

If one detects the virus's genetic material in a sample through PCR, it means that subject is very likely contaminated. If one tests negative, one still has a small (<10%) chance of a false-negative.

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PostPosted: Tue May 12, 2020 3:46 am 
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The beauty of recombinant DNA. Art, transgenic GFP expressing yeast on LB agar culture medium:

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PostPosted: Tue May 12, 2020 4:56 am 
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The more I read about DNA the more my mind is blown.....

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